Plasma proteome association with coronary heart disease and carotid intima media thickness: results from the KORA F4 study.

ABSTRACT:

Background and aims

Atherosclerosis is the main cause of stroke and coronary heart disease (CHD), both leading mortality causes worldwide. Proteomics, as a high-throughput method, could provide helpful insights into the pathological mechanisms underlying atherosclerosis. In this study, we characterized the associations of plasma protein levels with CHD and with carotid intima-media thickness (CIMT), as a surrogate measure of atherosclerosis.

Methods

The discovery phase included 1000 participants from the KORA F4 study, whose plasma protein levels were quantified using the aptamer-based SOMAscan proteomics platform. We evaluated the associations of plasma protein levels with CHD using logistic regression, and with CIMT using linear regression. For both outcomes we applied two

SUBMITTER: Elhadad MA 

PROVIDER: S-EPMC11138055 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature