Association of brain arterial diameters with demographic and anatomical factors in a multi-national pooled analysis of cohort studies.

ABSTRACT:

Background and purpose

Brain arterial diameters are markers of cerebrovascular disease. Demographic and anatomical factors may influence arterial diameters. We hypothesize that age, sex, height, total cranial volume (TCV), and persistent fetal posterior cerebral artery (fPCA) correlate with brain arterial diameters across populations.

Methods

Participants had a time-of-flight MRA from nine international cohorts. Arterial diameters of the cavernous internal carotid arteries (ICA), middle cerebral arteries (MCA), and basilar artery (BA) were measured using LAVA software. Regression models assessed the association between exposures and brain arterial diameters.

Results

We included 6,518 participants (mean age: 70 ± 9 years; 41% men). Unilateral fPCA was present in 13.2%

SUBMITTER: Del Brutto VJ 

PROVIDER: S-EPMC11138338 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature