Kdm6b Regulates the Generation of Effector CD8⁺ T Cells by Inducing Chromatin Accessibility in Effector-Associated Genes.

ABSTRACT: The transcriptional and epigenetic regulation of CD8⁺ T cell differentiation is critical for balancing pathogen eradication and long-term immunity by effector and memory CTLs, respectively. In this study, we demonstrate that the lysine demethylase 6b (Kdm6b) is essential for the proper generation and function of effector CD8⁺ T cells during acute infection and tumor eradication. We found that cells lacking Kdm6b (by either T cell-specific knockout mice or knockdown using short hairpin RNA strategies) show an enhanced generation of memory precursor and early effector cells upon acute viral infection in a cell-intrinsic manner. We also demonstrate that Kdm6b is indispensable for proper effector functions and tumor protection, and that memory CD8⁺ T cells lack

SUBMITTER: Xu T 

PROVIDER: S-EPMC11139061 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature