Integrated analysis of colorectal cancer metastasis identifies characteristics of tumor cell during metastasis.

ABSTRACT:

Background

Metastasis is the main cause of death in colorectal cancer (CRC). Metastasis is a sequential and dynamic process, but the development of tumor cells during this process is unclear. In this study, we aimed to reveal characteristics of tumor cell subset during CRC metastasis.

Methods

Single-cell RNA sequence CRC data of normal epithelium, non-metastatic primary tumor, metastatic primary tumor, and liver metastases from gene expression omnibus (GEO) dataset were analyzed to reveal characteristics of CRC metastasis. Primary tumor tissues of three non-metastatic CRC and three metastatic CRC patients from Union Hospital of Tongji Medical College (Wuhan, China) were used to verify the characteristics of CRC metastasis.

Results

We identified a metastasis-related ca

SUBMITTER: Fu H 

PROVIDER: S-EPMC11139507 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature