Differential effects of high-fat diet on endocrine, metabolic and depressive-like behaviors in male and female rats.

ABSTRACT: The complications of obesity extend beyond the periphery to the central nervous system (CNS) and include an increased risk of developing neuropsychiatric co-morbidities like depressive illness. Preclinical studies support this concept, including studies that have examined the effects of a high-fat diet (HFD) on depressive-like behaviors. Although women are approximately two-fold more likely to develop depressive illness compared to men, most preclinical studies have focused on the effects of HFD in male rodents. Accordingly, the goal of this study was to examine depressive-like behaviors in male and female rats provided access to a HFD. In agreement with prior studies, male and female rats provided a HFD segregate into an obesity phenotype (i.e., diet-induced obesity; DIO) or a diet resist

SUBMITTER: Woodruff JL 

PROVIDER: S-EPMC11139556 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature