The bacterial DNA sliding clamp, β-clamp: structure, interactions, dynamics and drug discovery.

ABSTRACT: DNA replication is a tightly coordinated event carried out by a multiprotein replication complex. An essential factor in the bacterial replication complex is the ring-shaped DNA sliding clamp, β-clamp, ensuring processive DNA replication and DNA repair through tethering of polymerases and DNA repair proteins to DNA. β -clamp is a hub protein with multiple interaction partners all binding through a conserved clamp binding sequence motif. Due to its central role as a DNA scaffold protein, β-clamp is an interesting target for antimicrobial drugs, yet little effort has been put into understanding the functional interactions of β-clamp. In this review, we scrutinize the β-clamp structure and dynamics, examine how its interactions with a plethora of binding partners are regulated through short l

SUBMITTER: Simonsen S 

PROVIDER: S-EPMC11139829 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature