CILP2 is a potential biomarker for the prediction and therapeutic target of peritoneal metastases in colorectal cancer.

ABSTRACT: Peritoneal metastases (PM) in colorectal cancer (CRC) is associated with a dismal prognosis. Identifying and exploiting new biomarkers, signatures, and molecular targets for personalised interventions in the treatment of PM in CRC is imperative. We conducted transcriptomic profiling using RNA-seq data generated from the primary tissues of 19 CRC patients with PM. Using our dataset established in a previous study, we identified 1422 differentially expressed genes compared to non-metastatic CRC. The profiling demonstrated no differential expression in liver and lung metastatic CRC. We selected 12 genes based on stringent criteria and evaluated their expression patterns in a validation cohort of 32 PM patients and 84 without PM using real-time reverse transcription-polymerase chain reaction.

SUBMITTER: Ha YJ 

PROVIDER: S-EPMC11139887 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature