Single-cell analysis of bronchoalveolar cells in inflammatory and fibrotic post-COVID lung disease.

ABSTRACT:

Background

Persistent radiological lung abnormalities are evident in many survivors of acute coronavirus disease 2019 (COVID-19). Consolidation and ground glass opacities are interpreted to indicate subacute inflammation whereas reticulation is thought to reflect fibrosis. We sought to identify differences at molecular and cellular level, in the local immunopathology of post-COVID inflammation and fibrosis.

Methods

We compared single-cell transcriptomic profiles and T cell receptor (TCR) repertoires of bronchoalveolar cells obtained from convalescent individuals with each radiological pattern, targeting lung segments affected by the predominant abnormality.

Results

CD4 central memory T cells and CD8 effector memory T cells were significantly more abundant in those wit

SUBMITTER: Mehta P 

PROVIDER: S-EPMC11140060 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature