The high-throughput solid-phase extraction of <i>cis</i>-cyclo(L-Leu-L-Pro) and <i>cis</i>-cyclo(L-Phe-L-Pro) from <i>Lactobacillus plantarum</i> demonstrates efficacy against multidrug-resistant bacteria and influenza A (H3N2) virus.

ABSTRACT: Introduction: 2,5-diketopiperazines are the simplest forms of cyclic dipeptides (CDPs) and have diverse frameworks with chiral side chains that are useful for drug development. Previous research has investigated the antimicrobial properties of proline-linked CDPs and their combinations in the culture filtrate (CF) of Lactobacillus plantarum LBP-K10 using anion exchange chromatography (AEC). However, the quantity of CDPs showcasing notable anti-influenza virus activity derived from AECs was generally lower than those originating from Lactobacillus CF. Methods: To address this issue, the study aims to propose a more efficient method for isolating CDPs and to introduce the antiviral combinations of CDPs obtained using a new method. The study employed a novel techni

SUBMITTER: Son J 

PROVIDER: S-EPMC11140067 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature