Exploring the gut microbiota-hippocampus-metabolites axis dysregulation in sepsis mice.

ABSTRACT:

Background

Sepsis is commonly associated with a sudden impairment of brain function, thus leading to significant rates of illness and mortality. The objective of this research was to integrate microbiome and metabolome to reveal the mechanism of microbiota-hippocampus-metabolites axis dysfunction in a mouse model of sepsis.

Methods

A mouse model of sepsis was established via cecal ligation and puncture. The potential associations between the composition of the gut microbiota and metabolites in the hippocampus of mice with sepsis were investigated by combining 16S ribosomal RNA gene sequencing and ultra-high-performance liquid chromatography tandem mass spectrometry.

Results

A total of 140 differential metabolites were identified in the hippocampal tissues of mice with

SUBMITTER: Song F 

PROVIDER: S-EPMC11140095 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature