Aluminum chloride and D-galactose induced a zebrafish model of Alzheimer's disease with cognitive deficits and aging.

ABSTRACT: Alzheimer's disease (AD) is an age-related neurodegenerative disorder. Transgenic and pharmacological AD models are extensively studied to understand AD mechanisms and drug discovery. However, they are time-consuming and relatively costly, which hinders the discovery of potential anti-AD therapeutics. Here, we established a new model of AD in larval zebrafish by co-treatment with aluminum chloride (AlCl₃) and D-galactose (D-gal) for 72 h. In particular, exposure to 150 μM AlCl₃ + 40 mg/mL D-gal, 200 μM AlCl₃ + 30 mg/mL D-gal, or 200 μM AlCl₃ + 40 mg/mL D-gal successfully induced AD-like symptoms and aging features. Co-treatment with AlCl₃ and D-gal caused significant learning and memory deficits, as well as impaired response ability an

SUBMITTER: Luo L 

PROVIDER: S-EPMC11140485 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature