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IFNγ at the early stage induced after cryo-thermal therapy maintains CD4⁺ Th1-prone differentiation, leading to long-term antitumor immunity.

ABSTRACT:

Introduction

Recently, more and more research illustrated the importance of inducing CD4⁺ T helper type (Th)-1 dominant immunity for the success of tumor immunotherapy. Our prior studies revealed the crucial role of CD4⁺ Th1 cells in orchestrating systemic and durable antitumor immunity, which contributes to the satisfactory outcomes of the novel cryo-thermal therapy in the B16F10 tumor model. However, the mechanism for maintaining the cryo-thermal therapy-mediated durable CD4⁺ Th1-dominant response remains uncovered. Additionally, cryo-thermal-induced early-stage CD4⁺ Th1-dominant T cell response showed a correlation with the favorable prognosis in patients with colorectal cancer liver metastasis (CRCLM). We hypothesized that CD4^+</

SUBMITTER: Wang J

PROVIDER: S-EPMC11140566 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature

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Dataset Information

IFNγ at the early stage induced after cryo-thermal therapy maintains CD4⁺ Th1-prone differentiation, leading to long-term antitumor immunity.

Introduction

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

IFNγ at the early stage induced after cryo-thermal therapy maintains CD4+ Th1-prone differentiation, leading to long-term antitumor immunity.

Introduction

OmicsDI is part of the ELIXIR infrastructure

Tweets

IFNγ at the early stage induced after cryo-thermal therapy maintains CD4⁺ Th1-prone differentiation, leading to long-term antitumor immunity.