Interfacing High-Throughput Electrosynthesis and Mass Spectrometric Analysis of Azines.

ABSTRACT: Combinatorial electrochemistry has great promise for accelerated reaction screening, organic synthesis, and catalysis. Recently, we described a new high-throughput electrochemistry platform, colloquially named "Legion". Legion fits the footprint of a 96-well microtiter plate with simultaneous individual control over all 96 electrochemical cells. Here, we demonstrate the versatility of Legion when coupled with high-throughput mass spectrometry (MS) for electrosynthetic product screening and quantitation. Electrosynthesis of benzophenone azine was selected as a model reaction and was arrayed and optimized using a combination of Legion and nanoelectrospray ionization MS. The combination of high-throughput synthesis with Legion and analysis via MS proves a compelling strategy for accelerating

SUBMITTER: Kulesa KM 

PROVIDER: S-EPMC11140680 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature