Extensive remodeling of sugar metabolism through gene loss and horizontal gene transfer in a eukaryotic lineage.

ABSTRACT:

Background

In yeasts belonging to the subphylum Saccharomycotina, genes encoding components of the main metabolic pathways, like alcoholic fermentation, are usually conserved. However, in fructophilic species belonging to the floral Wickerhamiella and Starmerella genera (W/S clade), alcoholic fermentation was uniquely shaped by events of gene loss and horizontal gene transfer (HGT).

Results

Because HGT and gene losses were first identified when only eight W/S-clade genomes were available, we collected publicly available genome data and sequenced the genomes of 36 additional species. A total of 63 genomes, representing most of the species described in the clade, were included in the analyses. Firstly, we inferred the phylogenomic tree of the clade and inspected the genomes fo

SUBMITTER: Pontes A 

PROVIDER: S-EPMC11140947 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature