Study on Allele Specific Expression of Long-Term Residents in High Altitude Areas.

ABSTRACT: In diploid organisms, half of the chromosomes in each cell come from the father and half from the mother. Through previous studies, it was found that the paternal chromosome and the maternal chromosome can be regulated and expressed independently, leading to the emergence of allele specific expression (ASE). In this study, we analyzed the differential expression of alleles in the high-altitude population and the normal population based on the RNA sequencing data. Through gene cluster analysis and protein interaction network analysis, we found some changes occurred at the gene level, and some negative effects. During the study, we realized that the calmodulin homology domain may have a certain correlation with long-term survival at high altitude. The plateau environment is characterized by

SUBMITTER: He C 

PROVIDER: S-EPMC11141219 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature