Microbiome in the nasopharynx: Insights into the impact of COVID-19 severity.

ABSTRACT:

Background

The respiratory tract harbors a variety of microbiota, whose composition and abundance depend on specific site factors, interaction with external factors, and disease. The aim of this study was to investigate the relationship between COVID-19 severity and the nasopharyngeal microbiome.

Methods

We conducted a prospective cohort study in Mexico City, collecting nasopharyngeal swabs from 30 COVID-19 patients and 14 healthy volunteers. Microbiome profiling was performed using 16S rRNA gene analysis. Taxonomic assignment, classification, diversity analysis, core microbiome analysis, and statistical analysis were conducted using R packages.

Results

The microbiome data analysis revealed taxonomic shifts within the nasopharyngeal microbiome in severe COVID-19. Part

SUBMITTER: Galeana-Cadena D 

PROVIDER: S-EPMC11141365 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature