Akt-2 Is a Potential Therapeutic Target for Disseminated Candidiasis.

ABSTRACT: Akt-1 and Akt-2 are the major isoforms of the serine/threonine Akt family that play a key role in controlling immune responses. However, the involvement of Akt-1 and Akt-2 isoforms in antifungal innate immunity is completely unknown. In this study, we show that Akt2 ^-/-, but not Akt1 ^-/-, mice are protected from lethal Candida albicans infection. Loss of Akt-2 facilitates the recruitment of neutrophils and macrophages to the spleen and increases reactive oxygen species expression in these cells. Treating C57BL/6 mice with a specific inhibitor for Akt-2, but not Akt-1, provides protection from lethal C. albicans infection. Our data demonstrate that Akt-2 inhibits antifungal innate immunity by hampering neutrophil and macrophage recruitment t

SUBMITTER: Huang L 

PROVIDER: S-EPMC11141526 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature