Gene expression and immune infiltration analysis comparing lesioned and preserved subchondral bone in osteoarthritis.

ABSTRACT:

Background

Osteoarthritis (OA) is a degenerative disease requiring additional research. This study compared gene expression and immune infiltration between lesioned and preserved subchondral bone. The results were validated using multiple tissue datasets and experiments.

Methods

Differentially expressed genes (DEGs) between the lesioned and preserved tibial plateaus of OA patients were identified in the GSE51588 dataset. Moreover, functional annotation and protein-protein interaction (PPI) network analyses were performed on the lesioned and preserved sides to explore potential therapeutic targets in OA subchondral bones. In addition, multiple tissues were used to screen coexpressed genes, and the expression levels of identified candidate DEGs in OA were measured by quantitat

SUBMITTER: Zhang G 

PROVIDER: S-EPMC11141552 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature