Spinal inhibitory neurons degenerate before motor neurons and excitatory neurons in a mouse model of ALS.

ABSTRACT: Amyotrophic lateral sclerosis (ALS) is characterized by the progressive loss of somatic motor neurons. A major focus has been directed to motor neuron intrinsic properties as a cause for degeneration, while less attention has been given to the contribution of spinal interneurons. In the present work, we applied multiplexing detection of transcripts and machine learning-based image analysis to investigate the fate of multiple spinal interneuron populations during ALS progression in the SOD1^G93A mouse model. The analysis showed that spinal inhibitory interneurons are affected early in the disease, before motor neuron death, and are characterized by a slow progressive degeneration, while excitatory interneurons are affected later with a steep progression. Moreover, we report differ

SUBMITTER: Montanana-Rosell R 

PROVIDER: S-EPMC11141618 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature