MR1-restricted T cell clonotypes are associated with "resistance" to Mycobacterium tuberculosis infection.

ABSTRACT: T cells are required for protective immunity against Mycobacterium tuberculosis. We recently described a cohort of Ugandan household contacts of tuberculosis cases who appear to "resist" M. tuberculosis infection (resisters; RSTRs) and showed that these individuals harbor IFN-γ-independent T cell responses to M. tuberculosis-specific peptide antigens. However, T cells also recognize nonprotein antigens via antigen-presenting systems that are independent of genetic background, known as donor-unrestricted T cells (DURTs). We used tetramer staining and flow cytometry to characterize the association between DURTs and "resistance" to M. tuberculosis infection. Peripheral blood frequencies of most DURT subsets were comparable between RSTRs and latently infected controls (LTBIs). However, we obse

SUBMITTER: Cross DL 

PROVIDER: S-EPMC11141901 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature