Multi-omics characterization of esophageal squamous cell carcinoma identifies molecular subtypes and therapeutic targets.

ABSTRACT: Esophageal squamous cell carcinoma (ESCC) is the predominant form of esophageal cancer and is characterized by an unfavorable prognosis. To elucidate the distinct molecular alterations in ESCC and investigate therapeutic targets, we performed a comprehensive analysis of transcriptomics, proteomics, and phosphoproteomics data derived from 60 paired treatment-naive ESCC and adjacent nontumor tissue samples. Additionally, we conducted a correlation analysis to describe the regulatory relationship between transcriptomic and proteomic processes, revealing alterations in key metabolic pathways. Unsupervised clustering analysis of the proteomics data stratified patients with ESCC into 3 subtypes with different molecular characteristics and clinical outcomes. Notably, subtype III exhibited the wor

SUBMITTER: Zhao D 

PROVIDER: S-EPMC11141925 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature