Murine modeling of menstruation identifies immune correlates of protection during <i>Chlamydia muridarum</i> challenge.

ABSTRACT: The menstrual cycle influences the risk of acquiring sexually transmitted infections (STIs), including Chlamydia trachomatis (C. trachomatis), although the underlying immune contributions are poorly defined. A mouse model simulating the immune-mediated process of menstruation could provide valuable insights into tissue-specific determinants of protection against chlamydial infection within the cervicovaginal and uterine mucosae comprising the female reproductive tract (FRT). Here, we used the pseudopregnancy approach in naïve C57Bl/6 mice and performed vaginal challenge with Chlamydia muridarum (C. muridarum) at decidualization, endometrial tissue remodeling, or uterine repair. This strategy identified that the time frame comprising uterine repair correlated wit

SUBMITTER: Lawrence LA 

PROVIDER: S-EPMC11142139 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature