Parietal cortex is causally required for state-dependent decisions.

ABSTRACT: During perceptual decision-making tasks, behavioral performance and its neural correlates vary with changes in internal states such as arousal, motivation, and strategy. It is not yet clear whether these state fluctuations differently impact the distributed neural processes that underlie task performance, from sensory processing to control of motor outputs. The posterior parietal cortex (PPC) is an association-level cortical region implicated in sensorimotor transformations, but evidence of its causal requirement in decision-making tasks has been contradictory. We trained mice to perform a navigation-based sound localization task and asked how natural fluctuations in behavioral state related to neural processing in association areas during decision-making. Behavioral performance in expert-

SUBMITTER: Bandi AC 

PROVIDER: S-EPMC11142168 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature