Parallel evolution of X chromosome-specific SMC complexes in two nematode lineages.

ABSTRACT: Mechanisms of X chromosome dosage compensation have been studied extensively in three model organisms that represent distinct clades. The diversity within each clade as a function of sex chromosome evolution though is largely unknown. Here, we anchor ourselves to the nematode Caenorhabditis elegans, where dosage compensation is accomplished by an X chromosome specific condensin that belongs to the family of structural maintenance of chromosomes (SMC) complexes. By combining a phylogenetic analyses of the C. elegans dosage compensation complex with a comparative analysis of its epigenetic signatures, such as X-specific topologically associating domains (TADs) and enrichment of H4K20me1, we show that the condensin-mediated mechanism evolved recently in the lineage leading to

SUBMITTER: Aharonoff A 

PROVIDER: S-EPMC11142195 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature