Causes and consequences of major depressive disorder: An encompassing Mendelian randomization study.

ABSTRACT:

Background

Major depressive disorder (MDD) is a prevalent and debilitating disorder that has been associated with a range of risk factors and outcomes. Causal pathways between MDD and other traits can be studied using genetic variants as instrumental variables.

Methods

A literature review was conducted to identify 201 MDD-associated traits. For 115 traits, there were well-powered genome-wide association study (GWAS) results available that could be used to assess the genetic correlation with MDD. Of these, there were 89 meeting criteria for investigating causal associations in both directions using two-sample Mendelian randomization (TSMR). Of the traits that were not captured by GWAS, 43 could be included as outcomes of MDD using one-sample MR (OSMR). A range of methods and

SUBMITTER: Pasman JA 

PROVIDER: S-EPMC11142270 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature