Dysregulation of miR-122, miR-574 and miR-375 in Egyptian patients with breast cancer.

ABSTRACT:

Background

The early detection of breast cancer (BC) is receiving global attention, creating an urgent need for more sensitive and comprehensive strategies for preventive intervention, therapy assessment, and prognosis prediction. Aberrant expression of miRNAs has been observed in various malignancies and may be potential targets for therapy. Our study aims to examine the expression profiles of miR-375, miR-574-3p, and miR-122 in the sera of Egyptian women with BC, benign breast lesions, and a control group. We hope to determine if these miRNAs can serve as minimally invasive biomarkers for BC.

Methods

This is a case-control study in which 77 patients with newly diagnosed BC, 20 patients with benign breast tumors, and 30 normal healthy subjects as controls were recruited fro

SUBMITTER: Elghoroury EA 

PROVIDER: S-EPMC11142443 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature