Neuronally differentiated macula densa cells regulate tissue remodeling and regeneration in the kidney.

ABSTRACT: Tissue regeneration is limited in several organs, including the kidney, contributing to the high prevalence of kidney disease globally. However, evolutionary and physiological adaptive responses and the presence of renal progenitor cells suggest an existing remodeling capacity. This study uncovered endogenous tissue remodeling mechanisms in the kidney that were activated by the loss of body fluid and salt and regulated by a unique niche of a minority renal cell type called the macula densa (MD). Here, we identified neuronal differentiation features of MD cells that sense the local and systemic environment and secrete angiogenic, growth, and extracellular matrix remodeling factors, cytokines and chemokines, and control resident progenitor cells. Serial intravital imaging, MD nerve growth fa

SUBMITTER: Gyarmati G 

PROVIDER: S-EPMC11142747 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature