Unraveling the links between circulating bioactive factors and epilepsy: A bidirectional Mendelian randomization study.

ABSTRACT: Epidemiological research has shown that a variety of circulating bioactive factors are associated with epilepsy, including macrophage colony-stimulating factor, interleukin-1β, and tumor necrosis factor-α. To further investigate the associations between epilepsy and 41 inflammatory cytokines, this Mendelian randomization was performed. This study presents genome-wide association study summary data on 41 inflammatory cytokines and epilepsy. Epilepsy incorporates generalized and focal epilepsy. A two-sample Mendelian randomization method was used. In order to analyze causal relationships between exposures and outcomes, the inverse variance-weighted method was mainly used. The findings suggested that increased levels of interleukin-1 receptor antagonists and interleukin-5 may be significantly

SUBMITTER: Wang W 

PROVIDER: S-EPMC11142776 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature