Gut microbiota metabolites and risk of major adverse cardiovascular events and death: A systematic review and meta-analysis.

ABSTRACT:

Background

Gut microbial metabolites such as trimethylamine N-oxide (TMAO) and its precursors, namely betaine, L-carnitine, and choline, have been implicated as risk factors for cardiovascular events and mortality development. Therefore, we aim to perform a systematic review and meta-analysis to assess the validity of these associations.

Methods

MEDLINE and Scopus were queried from their inception to August 2023 to identify studies that quantified estimates of the associations of TMAO with the development of major adverse cardiovascular events (MACE) or death. A random-effects meta-analysis was conducted to pool unadjusted or multivariable-adjusted hazard ratios (HR) and their 95% confidence intervals. The primary endpoint was the risk of MACE and all-cause death.

Results

SUBMITTER: Khan QA 

PROVIDER: S-EPMC11142832 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature