Quantitative analysis of Tr1 lymphocytes in patients with type 2 diabetes mellitus.

ABSTRACT:

Background

Type 2 diabetes mellitus (T2DM) is usually accompanied by a low-grade inflammatory phenomenon, which participates in the pathogenesis of different complications of this condition. The inflammatory response is under the regulation of different mechanisms, including T regulatory (Treg) lymphocytes. However, the possible role of type 1 T regulatory (Tr1) cells in T2DM has not been explored so far.

Aim

To carry out a quantitative analysis of Tr1 lymphocytes and other immune cell subsets in patients with T2DM and correlate these results with clinical findings and treatments.

Materials and methods

Sixty patients with T2DM and twenty-three healthy controls were included in the study. Biochemical and anthropometric variables were evaluated, and Tr1 lymphocytes (CD4

SUBMITTER: Knott-Torcal C 

PROVIDER: S-EPMC11142976 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature