Glycolysis inhibition induces anti-tumor central memory CD8⁺T cell differentiation upon combination with microwave ablation therapy.

ABSTRACT: Minimally invasive thermal therapy is a successful alternative treatment to surgery in solid tumors with high complete ablation rates, however, tumor recurrence remains a concern. Central memory CD8⁺ T cells (T_CM) play important roles in protection from chronic infection and cancer. Here we find, by single-cell RNA analysis of human breast cancer samples, that although the memory phenotype of peripheral CD8⁺ T cells increases slightly after microwave ablation (MWA), the metabolism of peripheral CD8⁺ T cells remains unfavorable for memory phenotype. In mouse models, glycolysis inhibition by 2-deoxy-D-glucose (2DG) in combination with MWA results in long-term anti-tumor effect via enhancing differentiation of tumor-specific CD44^hiCD62L

SUBMITTER: Tang X 

PROVIDER: S-EPMC11143264 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature