Pulmonary arterial hypertension treatment: an individual participant data network meta-analysis.

ABSTRACT:

Background and aims

Effective therapies that target three main signalling pathways are approved to treat pulmonary arterial hypertension (PAH). However, there are few large patient-level studies that compare the effectiveness of these pathways. The aim of this analysis was to compare the effectiveness of the treatment pathways in PAH and to assess treatment heterogeneity.

Methods

A network meta-analysis was performed using individual participant data of 6811 PAH patients from 20 Phase III randomized clinical trials of therapy for PAH that were submitted to the US Food and Drug Administration. Individual drugs were grouped by the following treatment pathways: endothelin, nitric oxide, and prostacyclin pathways.

Results

The mean (±standard deviation) age of the sample w

SUBMITTER: Moutchia J 

PROVIDER: S-EPMC11143388 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature