IL-15 reprogramming compensates for NK cell mitochondrial dysfunction in HIV-1 infection.

ABSTRACT: Dynamic regulation of cellular metabolism is important for maintaining homeostasis and can directly influence immune cell function and differentiation, including NK cell responses. Persistent HIV-1 infection leads to a state of chronic immune activation, NK cell subset redistribution, and progressive NK cell dysregulation. In this study, we examined the metabolic processes that characterize NK cell subsets in HIV-1 infection, including adaptive NK cell subpopulations expressing the activating receptor NKG2C, which expand during chronic infection. These adaptive NK cells exhibit an enhanced metabolic profile in HIV-1- individuals infected with human cytomegalovirus (HCMV). However, the bioenergetic advantage of adaptive CD57+NKG2C+ NK cells is diminished during chronic HIV-1 infection, wher

SUBMITTER: Moreno-Cubero E 

PROVIDER: S-EPMC11143930 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature