Dynamic injectable tissue adhesives with strong adhesion and rapid self-healing for regeneration of large muscle injury.

ABSTRACT: Wounds often necessitate the use of instructive biomaterials to facilitate effective healing. Yet, consistently filling the wound and retaining the material in place presents notable challenges. Here, we develop a new class of injectable tissue adhesives by leveraging the dynamic crosslinking chemistry of Schiff base reactions. These adhesives demonstrate outstanding mechanical properties, especially in regard to stretchability and self-healing capacity, and biodegradability. Furthermore, they also form robust adhesion to biological tissues. Their therapeutic potential was evaluated in a rodent model of volumetric muscle loss (VML). Ultrasound imaging confirmed that the adhesives remained within the wound site, effectively filled the void, and degraded at a rate comparable to the healing p

SUBMITTER: Nam S 

PROVIDER: S-EPMC11144078 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature