The potent potential of MFAP2 in prognosis and immunotherapy of triple-negative breast cancer.

ABSTRACT:

Backgrounds

Microfibril-associated protein 2 (MFAP2) is a protein presenting in the extracellular matrix that governs the activity of microfibrils through its interaction with fibrillin. While the involvement of MFAP2 in metabolic disorders has been documented, its expression and prognostic significance in triple-negative breast cancer (TNBC) remain unexplored.

Methods

We acquired datasets pertaining to breast cancer (BC) from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases. Next, a Venn diagram was used to identify the differentially expressed genes (DEGs). The DEGs were used to perform Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), protein-protein interaction (PPI), immune and survival analysis. The expressions of MFAP2,

SUBMITTER: Huang J 

PROVIDER: S-EPMC11144179 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature