Hyperpolarized ¹³C Metabolic MRI of Patients with Pancreatic Ductal Adenocarcinoma.

ABSTRACT:

Background

Pancreatic ductal adenocarcinoma (PDA) is the third leading cause of cancer-related death in the United States. However, early response assessment using the current approach of measuring changes in tumor size on computed tomography (CT) or MRI is challenging.

Purpose

To investigate the feasibility of hyperpolarized (HP) [1-¹³C]pyruvate MRI to quantify metabolism in the normal appearing pancreas and PDA, and to assess changes in PDA metabolism following systemic chemotherapy.

Study type

Prospective.

Subjects

Six patients (65.0 ± 7.6 years, 2 females) with locally advanced or metastatic PDA enrolled prior to starting a new line of systemic chemotherapy.

Field strength/sequence

3-T, T1-weighted gradient echo, metabolite-selective

SUBMITTER: Gordon JW 

PROVIDER: S-EPMC11144260 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature