Motor Complications in Parkinson's Disease: Results from 3343 Patients Followed for up to 12 Years.

ABSTRACT:

Background

Motor complications are well recognized in Parkinson's disease (PD), but their reported prevalence varies and functional impact has not been well studied.

Objectives

To quantify the presence, severity, impact and associated factors for motor complications in PD.

Methods

Analysis of three large prospective cohort studies of recent-onset PD patients followed for up to 12 years. The MDS-UPDRS part 4 assessed motor complications and multivariable logistic regression tested for associations. Genetic risk score (GRS) for Parkinson's was calculated from 79 single nucleotide polymorphisms.

Results

3343 cases were included (64.7% male). Off periods affected 35.0% (95% CI 33.0, 37.0) at 4-6 years and 59.0% (55.6, 62.3) at 8-10 years. Dyskinesia affected 18.5%

SUBMITTER: Gandhi SE 

PROVIDER: S-EPMC11145112 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature