MFN2 suppresses the accumulation of lipid droplets and the progression of clear cell renal cell carcinoma.

ABSTRACT: Dissolving the lipid droplets in tissue section with alcohol during a hematoxylin and eosin (H&E) stain causes the tumor cells to appear like clear soap bubbles under a microscope, which is a key pathological feature of clear cell renal cell carcinoma (ccRCC). Mitochondrial dynamics have been reported to be closely associated with lipid metabolism and tumor development. However, the relationship between mitochondrial dynamics and lipid metabolism reprogramming in ccRCC remains to be further explored. We conducted bioinformatics analysis to identify key genes regulating mitochondrial dynamics differentially expressed between tumor and normal tissues and immunohistochemistry and Western blot to confirm. After the target was identified, we created stable ccRCC cell lines to test the impact of

SUBMITTER: Cai Z 

PROVIDER: S-EPMC11145141 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature