Unraveling malignant phenotype of peritumoral tissue: transcriptomic insights into early-stage breast cancer.

ABSTRACT:

Background

Early-stage invasive ductal carcinoma displays high survival rates due to early detection and treatments. However, there is still a chance of relapse of 3-15% after treatment. The aim of this study was to uncover the distinctive transcriptomic characteristics and monitoring prognosis potential of peritumoral tissue in early-stage cases.

Methods

RNA was isolated from tumoral, peritumoral, and non-tumoral breast tissue from surgical resection of 10 luminal early-stage invasive ductal carcinoma patients. Transcriptome expression profiling for differentially expressed genes (DEGs) identification was carried out through microarray analysis. Gene Ontology and KEGG pathways enrichment analysis were explored for functional characterization of identified DEGs. Protein-Prot

SUBMITTER: Morla-Barcelo PM 

PROVIDER: S-EPMC11145834 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature