Gut microbiota alterations in postmenopausal women with osteoporosis and osteopenia from Shanghai, China.

ABSTRACT:

Background

The importance of the gut microbiota in maintaining bone homeostasis has been increasingly emphasized by recent research. This study aimed to identify whether and how the gut microbiome of postmenopausal women with osteoporosis and osteopenia may differ from that of healthy individuals.

Methods

Fecal samples were collected from 27 individuals with osteoporosis (OP), 44 individuals with osteopenia (ON), and 23 normal controls (NC). The composition of the gut microbial community was analyzed by 16S rRNA gene sequencing.

Results

No significant difference was found in the microbial composition between the three groups according to alpha and beta diversity. At the phylum level, Proteobacteria and Fusobacteriota were significantly higher and Syne

SUBMITTER: Ji J 

PROVIDER: S-EPMC11146318 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature