Seizures exacerbate excitatory: inhibitory imbalance in Alzheimer's disease and 5XFAD mice.

ABSTRACT: Approximately 22% of Alzheimer's disease (AD) patients suffer from seizures, and the co-occurrence of seizures and epileptiform activity exacerbates AD pathology and related cognitive deficits, suggesting that seizures may be a targetable component of AD progression. Given that alterations in neuronal excitatory:inhibitory (E:I) balance occur in epilepsy, we hypothesized that decreased markers of inhibition relative to those of excitation would be present in AD patients. We similarly hypothesized that in 5XFAD mice, the E:I imbalance would progress from an early stage (prodromal) to later symptomatic stages and be further exacerbated by pentylenetetrazol (PTZ) kindling. Post-mortem AD temporal cortical tissues from patients with or without seizure history were examined for changes in sever

SUBMITTER: Barbour AJ 

PROVIDER: S-EPMC11146435 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature