Ribosome decision graphs for the representation of eukaryotic RNA translation complexity.

ABSTRACT: The application of ribosome profiling has revealed an unexpected abundance of translation in addition to that responsible for the synthesis of previously annotated protein-coding regions. Multiple short sequences have been found to be translated within single RNA molecules, within both annotated protein-coding and noncoding regions. The biological significance of this translation is a matter of intensive investigation. However, current schematic or annotation-based representations of mRNA translation generally do not account for the apparent multitude of translated regions within the same molecules. They also do not take into account the stochasticity of the process that allows alternative translations of the same RNA molecules by different ribosomes. There is a need for formal representat

SUBMITTER: Tierney JAS 

PROVIDER: S-EPMC11146595 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature