Hippocampo-cortical circuits for selective memory encoding, routing, and replay.

ABSTRACT: Traditionally considered a homogeneous cell type, hippocampal pyramidal cells have been recently shown to be highly diverse. However, how this cellular diversity relates to the different hippocampal network computations that support memory-guided behavior is not yet known. We show that the anatomical identity of pyramidal cells is a major organizing principle of CA1 assembly dynamics, the emergence of memory replay, and cortical projection patterns in rats. Segregated pyramidal cell subpopulations encoded trajectory and choice-specific information or tracked changes in reward configuration respectively, and their activity was selectively read out by different cortical targets. Furthermore, distinct hippocampo-cortical assemblies coordinated the reactivation of complementary memory represen

SUBMITTER: Harvey RE 

PROVIDER: S-EPMC11146684 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature