A liquid biopsy assay for the noninvasive detection of lymph node metastases in T1 lung adenocarcinoma.

ABSTRACT:

Introduction

Lung adenocarcinoma (LUAD) is a common pathological type of lung cancer. The presence of lymph node metastasis plays a crucial role in determining the overall treatment approach and long-term prognosis for early LUAD, therefore accurate prediction of lymph node metastasis is essential to guide treatment decisions and ultimately improve patient outcomes.

Methods

We performed transcriptome sequencing on T1 LUAD patients with positive or negative lymph node metastases and combined this data with The Cancer Genome Atlas Program cohort to identify potential risk molecules at the tissue level. Subsequently, by detecting the expression of these risk molecules by real-time quantitative PCR in serum samples, we developed a model to predict the risk of lymph node metastas

SUBMITTER: Li X 

PROVIDER: S-EPMC11147666 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature