Disentangling differing relationships between internalizing disorders and alcohol use.

ABSTRACT: Both internalizing disorders and alcohol use have dramatic, wide-spread implications for global health. Previous work has established common phenotypic comorbidity among these disorders, as well as shared genetic variation underlying them both. We used genomic structural equation modeling to investigate the shared genetics of internalizing, externalizing, and alcohol use traits, as well as to explore whether specific domains of internalizing symptoms mediate the contrasting relationships with problematic alcohol use compared to alcohol consumption. We also examined patterns of genetic correlations between similar traits within additional Finnish and East Asian ancestry groups. When the shared genetic influence of externalizing psychopathology was accounted for, the genetic effect of intern

SUBMITTER: Brasher MS 

PROVIDER: S-EPMC11147714 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature