Falls, fracture and frailty risk in multiple sclerosis: a Mendelian Randomization study to identify shared genetics.

ABSTRACT:

Introduction

Patients with multiple sclerosis (MS) commonly present musculoskeletal disorders characterized by lower bone mineral density (BMD) and muscle weakness. However, the underlying etiology remains unclear. Our objective is to identify shared pleiotropic genetic effects and estimate the causal relationship between MS and musculoskeletal disorders.

Materials and methods

We conducted linkage disequilibrium score regression (LDSR), colocalization, and Mendelian randomization (MR) analyses using summary statistics from recent large-scale genome-wide association studies (GWAS), encompassing MS, falls, fractures, and frailty. Additional MR analyses explored the causal relationship with musculoskeletal risk factors, such as BMD, lean mass, grip strength, and vitamin D.

R

SUBMITTER: Jeong S 

PROVIDER: S-EPMC11147890 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature