Transient PU.1 low fetal progenitors generate lymphoid progeny that contribute to adult immunity.

ABSTRACT: Hematopoietic stem cells and multipotential progenitors emerge in multiple, overlapping waves of fetal development. Some of these populations seed the bone marrow and sustain adult B- and T-cell development long-term after birth. However, others are present transiently, but whether they are vestigial or generate B and T cells that contribute to the adult immune system is not well understood. We now report that transient fetal progenitors distinguished by expression of low levels of the PU.1 transcription factor generated activated and memory T and B cells that colonized and were maintained in secondary lymphoid tissues. These included the small and large intestines, where they may contribute to the maintenance of gut homeostasis through at least middle age. At least some of the activated/m

SUBMITTER: Montecino-Rodriguez E 

PROVIDER: S-EPMC11147949 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature