Repeated caffeine intake suppresses cerebral grey matter responses to chronic sleep restriction in an A₁ adenosine receptor-dependent manner: a double-blind randomized controlled study with PET-MRI.

ABSTRACT: Evidence has shown that both sleep loss and daily caffeine intake can induce changes in grey matter (GM). Caffeine is frequently used to combat sleepiness and impaired performance caused by insufficient sleep. It is unclear (1) whether daily use of caffeine could prevent or exacerbate the GM alterations induced by 5-day sleep restriction (i.e. chronic sleep restriction, CSR), and (2) whether the potential impact on GM plasticity depends on individual differences in the availability of adenosine receptors, which are involved in mediating effects of caffeine on sleep and waking function. Thirty-six healthy adults participated in this double-blind, randomized, controlled study (age = 28.9 ± 5.2 y/; F:M = 15:21; habitual level of caffeine intake < 450 mg; 29 homozygous C/C allele carriers of r

SUBMITTER: Lin YS 

PROVIDER: S-EPMC11148136 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature