Dynamic control of gene expression by ISGF3 and IRF1 during IFNβ and IFNγ signaling.

ABSTRACT: Type I interferons (IFN-I, including IFNβ) and IFNγ produce overlapping, yet clearly distinct immunological activities. Recent data show that the distinctness of global transcriptional responses to the two IFN types is not apparent when comparing their immediate effects. By analyzing nascent transcripts induced by IFN-I or IFNγ over a period of 48 h, we now show that the distinctiveness of the transcriptomes emerges over time and is based on differential employment of the ISGF3 complex as well as of the second-tier transcription factor IRF1. The distinct transcriptional properties of ISGF3 and IRF1 correspond with a largely diverse nuclear protein interactome. Mechanistically, we describe the specific input of ISGF3 and IRF1 into enhancer activation and the regulation of chromatin accessib

SUBMITTER: Ravi Sundar Jose Geetha A 

PROVIDER: S-EPMC11148166 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature