Basic host response parameters to classify mortality risk in COVID-19 and community-acquired pneumonia.

ABSTRACT: Improved phenotyping in pneumonia is necessary to strengthen risk assessment. Via a feasible and multidimensional approach with basic parameters, we aimed to evaluate the effect of host response at admission on severity stratification in COVID-19 and community-acquired pneumonia (CAP). Three COVID-19 and one CAP multicenter cohorts including hospitalized patients were recruited. Three easily available variables reflecting different pathophysiologic mechanisms-immune, inflammation, and respiratory-were selected (absolute lymphocyte count [ALC], C-reactive protein [CRP] and, SpO₂/FiO₂). In-hospital mortality and intensive care unit (ICU) admission were analyzed as outcomes. A multivariable, penalized maximum likelihood logistic regression was performed with ALC (< 724 l

SUBMITTER: Menendez R 

PROVIDER: S-EPMC11148180 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature